Endocrine Abstracts

Background: Clinical features of acromegaly develop insidiously and the diagnosis is often delayed. However, diagnostic delay (DD) in acromegaly has not been systematically investigated. Our primary aim was to investigate DD in a nationwide cohort of patients with acromegaly. Secondary aim was to study the impact of DD on morbidity and mortality.Methods: Adult patients diagnosed with acromegaly between 2001 and 2013 were identified in the Swedish Nationa...

Introduction: Graves’ dermopathy (also known as pretibial myxedema, thyroid dermopathy, Jadassohn-Dösseker disease or myxedema tuberosum) is a rare extrathyroidal manifestation of Graves’ disease, which is almost always associated with Graves’ ophthalmopathy. Although pretibial myxedema is the most frequent localization of Graves’ dermopathy, the involvement of toes with or without the involvement of pretibial area may occur.Obje...

Introduction: Suppression of TSH usually indicates hyperthyroidism. But the etiology of low TSH is very wide, including pituitary pathology. In this report we describe a case diagnosed and treated for hyperthyroidism. Later on, the persistence of suppressed TSH after therapy of hyperthyroidism was due to a GH-secreting pituitary adenoma.Case presentation: A 47-year old woman was referred to our clinic for investigations, due to thyroid pathology. The pat...

Introduction: Somatostatin analogues (SSA) have been used as first line treatment to control the symtoms in hormonally active neuroendocrine tumors (NET), for over three decades. Primary hepatic neuroendocrine tumors (PHNETs) are rare neoplasms. Despite increased incidence of PHNETs over time, these tumors remain a rarity. According to the previously reported cases, primary neuroendocrine carcinoma of the liver is usually multicentric, often mimicking liver metastases. The dem...

Tc-99m sestamibi (MIBI) imaging is able to localize parathyroid adenomas/carcinomas in patients with primary hyperparathyroidism. Brown tumours are one of the skeletal manifestations of long standing hyperparathyroidism and its incidence has been reported to be 3%. Radiological features of these tumors may mimic bone metastasis. There are only a few reports showing brown tumours uptake in the whole-body Tc-sestamibi scan.We report a 72-year-old female wi...

Introduction: Hodgkin lymphoma (HL) survivors may develop a range of long-term complications that arise years after therapy. Among these, the endocrine dysfunctions are a major concern. Aim: To investigate the long-term endocrine effects of HL treatment.Methods: Revision of the HL patients’ medical files who were followed at our Endocrine Late-effects Clinics.Results: We studied 178 patients (86 (48.3%) were female), whose mea...

Context: Many pediatric cancer survivors have endocrine conditions. After alkylating agents, steroids, methotrexate and radiation, several endocrine dysfunctions may appear. Surveillance for late effects is recommended by worldwide guidelines.Objective: The objective of the study was to describe the endocrine outcomes of 764 patients followed during a 20 years period in our out-patient clinic.Design: The design was a retrospective ...

Impaired 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2)-dependent cortisol inactivation can lead to electrolyte dysbalance, hypertension and cardiometabolic disease. Furthermore, placental 11β-HSD2 essentially protects the fetus from high maternal glucocorticoid levels, and its impaired function has been associated with altered fetal growth and a higher risk for cardio-metabolic diseases in later life. Despite its important role, 11β-HSD2 is not include...

Introduction: Acromegaly is a rare, serious disease caused by the presence of a pituitary adenoma secreting an excessive amount of growth hormone (GH), which leads to a consequent increase in circulating insulin-like growth factor-1 (IGF-1) levels, and excessive skeletal growth and soft tissue enlargement. It is usually managed by surgery and/or treatment with somatostatin analogs (SSA). The ACRONIS study (CSOM230CIC05) will provide real-world evidence on the efficacy and safe...

Introduction: Chemotherapy may be an important cause of primary infertility, especially in girls submitted to this therapy at very young ages.Clinical case: A 20-year-old female was diagnosed with acute lymphoblastic leukaemia at the age of 1. She was submitted to chemotherapy: intrathecal methotrexate and cyclophosphamide and i.v. doxorubicin, vincristine, mercaptopurine, asparaginase and bone marrow transplantation at the age of 2. She was ref...